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ea0037oc4.3 | Diabetes | ECE2015

Chronic, long-term administration of Vardenafil improves endothelial function and corrects hypogonadism in patients with type 2 diabetes mellitus. A longitudinal, prospective, randomized, placebo-controlled, double blind, clinical trial

Santi Daniele , Guidi Alessandro , Granata Antonio , Pignatti Elisa , Bozic Roberto , Zaza Stefano , Roli Laura , Trenti Tommaso , Carani Cesare , Simoni Manuela

Background: Endothelial dysfunction leads to cardiovascular complications in type 2 diabetes mellitus (T2DM), through a reduction of nitric oxide (NO)-mediated relaxation. Phosphodiesterase-5 inhibitors (PDE5i) have hemodynamic effects, improving NO levels.Aim: To investigate if long term, chronic treatment with the PDE5i Vardenafil improves systemic endothelial function in men with T2DM.Methods: A longitudinal, prospective, invest...

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ea0093oc32 | Oral communication 5: Reproductive Endocrinology | EYES2023

Follicle stimulating hormone in male idiopathic infertility: How to predict its efficacy?

Romeo Marilina , Spaggiari Giorgia , Valentina Leonardo Dalla , Nuzzo Federico , Roli Laura , Santis Maria Cristina De , Trenti Tommaso , Granata Antonio R. M. , Simoni Manuela , Santi Daniele

Background: Testis stimulation with follicle stimulating hormone (FSH) is one of the empirical treatments proposed for male idiopathic infertility, although early reliable markers to predict its efficacy are still lacking.Objective: To identify the improvement of semen parameters required to predict a priori FSH efficacy in terms of pregnancy achievement.Methods: A real-world study was conducted, enrolling idiopathic infer...

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ea0093oc34 | Oral communication 5: Reproductive Endocrinology | EYES2023

Testosterone serum levels in idiopathic male infertility: An epidemiological insight with pathophysiological and clinical consequences

Costantino Francesco , Spaggiari Giorgia , Valentina Leonardo Dalla , Romeo Marilina , Roli Laura , De Santis Maria Cristina , Trenti Tommaso , Granata Antonio , Simoni Manuela , Santi Daniele

Background: Despite male idiopathic infertility is characterized by semen analysis alteration with gonadotropins within reference ranges, it is still considered a functional hypogonadotropic hypogonadism (FHH). This simple definition is fundamental to guide the empirical therapeutic approach of these men. However, the number of studies describing total testosterone serum levels (TT) in male idiopathic infertility is still limited.Objective: To evaluate T...

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ea0090oc2.1 | Oral Communications 2: Thyroid | ECE2023

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

Brigante Giulia , Santi Daniele , Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Roy Neena , Casarini Livio , Trenti Tommaso , Varani Manuela , De Santis Maria Cristina , Roli Laura , Rochira Vincenzo , Simoni Manuela

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...

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ea0063p320 | Reproductive Endocrinology 1 | ECE2019

Gonadal Function in Human Immunodeficiency Virus (HIV)-Infected Men: comparison between Isotopic Dilution-Liquid Chromatography-Tandem Mass Spectrometry (ID-LC-MS/MS) and Chemiluminescent Immunoassay (CI)

De Vincentis Sara , Decaroli Maria Chiara , Fanelli Flaminia , Mezzullo Marco , Diazzi Chiara , Morini Fabio , Bertani Davide , Santi Daniele , Baraldi Enrica , Tagliavini Simonetta , Roli Laura , Trenti Tommaso , Pagotto Uberto , Guaraldi Giovanni , Rochira Vincenzo

Background: HIV-infection is associated to premature decline of serum T. However, prevalence and biochemical characterization of hypogonadism in HIV-infected men are still to be well defined.Aim: To evaluate the gonadal status in HIV-infected men by assessing circulating total T (TT) with either ID-LC-MS/MS or CI.Methods: Prospective, cross-sectional, observational study on HIV-infected men with ongoing Highly Active Antiretroviral...